Conservative mutations in the C2 domains of factor VIII and factor V alter phospholipid binding and cofactor activity

Factor VIII and factor V share structural homology and bind to phospholipid membranes via tandem, lectin-like C domains. Their respective C2 domains bind via 2 pairs of hydrophobic amino acids and an amphipathic cluster. In contrast, the factor V-like, homologous subunit (Pt-FV) of a prothrombin act...

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Bibliographic Details
Main Authors: Gilbert, Gary E., Novakovic, Valerie A., Kaufman, Randal J., Miao, Hongzhi, Pipe, Steven W.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2012
Subjects:
Thrombosis and Hemostasis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433094/
https://ncbi.nlm.nih.gov/pubmed/22613792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-408245
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