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Conservative mutations in the C2 domains of factor VIII and factor V alter phospholipid binding and cofactor activity
Factor VIII and factor V share structural homology and bind to phospholipid membranes via tandem, lectin-like C domains. Their respective C2 domains bind via 2 pairs of hydrophobic amino acids and an amphipathic cluster. In contrast, the factor V-like, homologous subunit (Pt-FV) of a prothrombin act...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society of Hematology
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3433094/ https://ncbi.nlm.nih.gov/pubmed/22613792 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-408245 |
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