In vivo efficacy of platelet-delivered, high specific activity factor VIII variants

Ectopically expressed, human B-domainless (hB) factor 8 (F8) in platelets improves hemostasis in hemophilia A mice in several injury models. However, in both a cuticular bleeding model and a cremaster laser arteriole/venule injury model, there were limitations to platelet-derived (p) hBF8 efficacy,...

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Autors principals: Greene, Teshell K., Wang, Cheng, Hirsch, Jessica D., Zhai, Li, Gewirtz, Jamie, Thornton, Michael A., Miao, Hongzhi Z., Pipe, Steven W., Kaufman, Randal J., Camire, Rodney M., Arruda, Valder R., Kowalska, M. Anna, Poncz, Mortimer
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2010
Matèries:
Thrombosis and Hemostasis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031396/
https://ncbi.nlm.nih.gov/pubmed/20852129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-06-293308
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