FLI1 level during megakaryopoiesis affects thrombopoiesis and platelet biology

Friend leukemia virus integration 1 (FLI1), a critical transcription factor (TF) during megakaryocyte differentiation, is among genes hemizygously deleted in Jacobsen syndrome, resulting in a macrothrombocytopenia termed Paris-Trousseau syndrome (PTSx). Recently, heterozygote human FLI1 mutations ha...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Vo, Karen K., Jarocha, Danuta J., Lyde, Randolph B., Hayes, Vincent, Thom, Christopher S., Sullivan, Spencer K., French, Deborah L., Poncz, Mortimer
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2017
Soggetti:
Platelets and Thrombopoiesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5492092/
https://ncbi.nlm.nih.gov/pubmed/28432223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-02-770958
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