Combinatorial Optimization of PEG Architecture and Hydrophobic Content Improves siRNA Polyplex Stability, Pharmacokinetics, and Potency In Vivo

A rationally-designed library of ternary siRNA polyplexes was developed and screened for gene silencing efficacy in vitro and in vivo with the goal of overcoming both cell-level and systemic delivery barriers. [2-(dimethylamino)ethyl methacrylate] (DMAEMA) was homopolymerized or colpolymerized (50 m...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:J Control Release
Autores principales: Werfel, Thomas A., Jackson, Meredith A., Kavanaugh, Taylor E., Kirkbride, Kellye C., Miteva, Martina, Giorgio, Todd D., Duvall, Craig
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484420/
https://ncbi.nlm.nih.gov/pubmed/28366646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2017.03.389
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares