Hydrolytic charge-reversal of PEGylated polyplexes enhances intracellular un-packaging and activity of siRNA

Hydrolytically degrading nano-polyplexes (HDG-NPs) that reverse charge through conversion of tertiary amines to carboxylic acids were investigated to improve intracellular un-packaging of siRNA and target gene silencing compared to a non-degradable analog (non-HDG-NPs). Both NP types comprised rever...

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Publicat a:J Biomed Mater Res A
Autors principals: Werfel, Thomas A., Swain, Corban, Nelson, Christopher E., Kilchrist, Kameron V., Evans, Brian C., Miteva, Martina, Duvall, Craig L.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5517028/
https://ncbi.nlm.nih.gov/pubmed/26691570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm.a.35629
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