Physicochemical and Biological Evaluation of siRNA Polyplexes Based on PEGylated Poly(amido amine)s

PURPOSE: Use of RNA interference as novel therapeutic strategy is hampered by inefficient delivery of its mediator, siRNA, to target cells. Cationic polymers have been thoroughly investigated for this purpose but often display unfavorable characteristics for systemic administration, such as interact...

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Autors principals: Vader, Pieter, van der Aa, Leonardus J., Engbersen, Johan F. J., Storm, Gert, Schiffelers, Raymond M.
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2011
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264854/
https://ncbi.nlm.nih.gov/pubmed/21833793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-011-0545-z
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