Combinatorial Optimization of PEG Architecture and Hydrophobic Content Improves siRNA Polyplex Stability, Pharmacokinetics, and Potency In Vivo

A rationally-designed library of ternary siRNA polyplexes was developed and screened for gene silencing efficacy in vitro and in vivo with the goal of overcoming both cell-level and systemic delivery barriers. [2-(dimethylamino)ethyl methacrylate] (DMAEMA) was homopolymerized or colpolymerized (50 m...

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Publicat a:J Control Release
Autors principals: Werfel, Thomas A., Jackson, Meredith A., Kavanaugh, Taylor E., Kirkbride, Kellye C., Miteva, Martina, Giorgio, Todd D., Duvall, Craig
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484420/
https://ncbi.nlm.nih.gov/pubmed/28366646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2017.03.389
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