Hydrophobic Interactions between Polymeric Carrier and Palmitic Acid-Conjugated siRNA Improve PEGylated Polyplex Stability and Enhance In Vivo Pharmacokinetics and Tumor Gene Silencing

Formation of stable, long-circulating siRNA polyplexes is a significant challenge in translation of intravenously-delivered, polymeric RNAi cancer therapies. Here, we report that siRNA hydrophobization through conjugation to palmitic acid (siPA) improves stability, in vivo pharmacokinetics, and tumo...

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Pubblicato in:Biomaterials
Autori principali: Sarett, Samantha, Werfel, Thomas A, Chandra, Irene, Jackson, Meredith A, Kavanaugh, Taylor E, Hattaway, Madison E, Giorgio, Todd D, Duvall, Craig L
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894661/
https://ncbi.nlm.nih.gov/pubmed/27163624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2016.04.017
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