Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing

Clinical translation of therapies based on small interfering RNA (siRNA) is hampered by siRNA's comprehensively poor pharmacokinetic properties, which necessitate molecule modifications and complex delivery strategies. We sought an alternative approach to commonly used nanoparticle carriers by...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Sarett, Samantha M., Werfel, Thomas A., Lee, Linus, Jackson, Meredith A., Kilchrist, Kameron V., Brantley-Sieders, Dana, Duvall, Craig L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558996/
https://ncbi.nlm.nih.gov/pubmed/28739942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621240114
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