Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing

Clinical translation of therapies based on small interfering RNA (siRNA) is hampered by siRNA's comprehensively poor pharmacokinetic properties, which necessitate molecule modifications and complex delivery strategies. We sought an alternative approach to commonly used nanoparticle carriers by...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sarett, Samantha M., Werfel, Thomas A., Lee, Linus, Jackson, Meredith A., Kilchrist, Kameron V., Brantley-Sieders, Dana, Duvall, Craig L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558996/
https://ncbi.nlm.nih.gov/pubmed/28739942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1621240114
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