Gal8 Visualization of Endosome Disruption Predicts Carrier-Mediated Biologic Drug Intracellular Bioavailability

Endolysosome entrapment is one of the key barriers to the therapeutic use of biologic drugs that act intracellularly. The screening of prospective nanoscale endosome-disrupting delivery technologies is currently limited by methods that are indirect and cumbersome. Here, we statistically validate Gal...

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Publicat a:ACS Nano
Autors principals: Kilchrist, Kameron V., Dimobi, Somtochukwu C., Jackson, Meredith A., Evans, Brian C., Werfel, Thomas A., Dailing, Eric A., Bedingfield, Sean K., Kelly, Isom B., Duvall, Craig L.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995262/
https://ncbi.nlm.nih.gov/pubmed/30629431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.8b05482
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