An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles

Peptides and biologics provide unique opportunities to modulate intracellular targets not druggable by conventional small molecules. Most peptides and biologics are fused with cationic uptake moieties or formulated into nanoparticles to facilitate delivery, but these systems typically lack potency d...

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Vydáno v:Nat Commun
Hlavní autoři: Evans, Brian C., Fletcher, R. Brock, Kilchrist, Kameron V., Dailing, Eric A., Mukalel, Alvin J., Colazo, Juan M., Oliver, Matthew, Cheung-Flynn, Joyce, Brophy, Colleen M., Tierney, John W., Isenberg, Jeffrey S., Hankenson, Kurt D., Ghimire, Kedar, Lander, Cynthia, Gersbach, Charles A., Duvall, Craig L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825215/
https://ncbi.nlm.nih.gov/pubmed/31676764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12906-y
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