An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles

Peptides and biologics provide unique opportunities to modulate intracellular targets not druggable by conventional small molecules. Most peptides and biologics are fused with cationic uptake moieties or formulated into nanoparticles to facilitate delivery, but these systems typically lack potency d...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Evans, Brian C., Fletcher, R. Brock, Kilchrist, Kameron V., Dailing, Eric A., Mukalel, Alvin J., Colazo, Juan M., Oliver, Matthew, Cheung-Flynn, Joyce, Brophy, Colleen M., Tierney, John W., Isenberg, Jeffrey S., Hankenson, Kurt D., Ghimire, Kedar, Lander, Cynthia, Gersbach, Charles A., Duvall, Craig L.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825215/
https://ncbi.nlm.nih.gov/pubmed/31676764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12906-y
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker