Zwitterionic Nanocarrier Surface Chemistry Improves siRNA Tumor Delivery and Silencing Activity Relative to Polyethylene Glycol

Although siRNA-based nanomedicines hold promise for cancer treatment, conventional siRNA–polymer complex (polyplex) nanocarrier systems have poor pharmacokinetics following intravenous delivery, hindering tumor accumulation. Here, we determined the impact of surface chemistry on the in vivo pharmaco...

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Pubblicato in:ACS Nano
Autori principali: Jackson, Meredith A, Werfel, Thomas A., Curvino, Elizabeth J., Yu, Fang, Kavanaugh, Taylor E., Sarett, Samantha M., Dockery, Mary D., Kilchrist, Kameron V., Jackson, Ayisha N., Giorgio, Todd D., Duvall, Craig L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919184/
https://ncbi.nlm.nih.gov/pubmed/28548843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.7b01110
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