Zwitterionic Nanocarrier Surface Chemistry Improves siRNA Tumor Delivery and Silencing Activity Relative to Polyethylene Glycol

Although siRNA-based nanomedicines hold promise for cancer treatment, conventional siRNA–polymer complex (polyplex) nanocarrier systems have poor pharmacokinetics following intravenous delivery, hindering tumor accumulation. Here, we determined the impact of surface chemistry on the in vivo pharmaco...

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Detalhes bibliográficos
Publicado no:ACS Nano
Main Authors: Jackson, Meredith A, Werfel, Thomas A., Curvino, Elizabeth J., Yu, Fang, Kavanaugh, Taylor E., Sarett, Samantha M., Dockery, Mary D., Kilchrist, Kameron V., Jackson, Ayisha N., Giorgio, Todd D., Duvall, Craig L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919184/
https://ncbi.nlm.nih.gov/pubmed/28548843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsnano.7b01110
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