Sensitivity to Sevoflurane anesthesia is decreased in mice with a congenital deletion of Guanylyl Cyclase-1 alpha

BACKGROUND: Volatile anesthetics increase levels of the neurotransmitter nitric oxide (NO) and the secondary messenger molecule cyclic guanosine monophosphate (cGMP) in the brain. NO activates the enzyme guanylyl cyclase (GC) to produce cGMP. We hypothesized that the NO-GC-cGMP pathway contributes t...

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Библиографические подробности
Опубликовано в: :BMC Anesthesiol
Главные авторы: Nagasaka, Yasuko, Wepler, Martin, Thoonen, Robrecht, Sips, Patrick Y., Allen, Kaitlin, Graw, Jan A., Yao, Vincent, Burns, Sara M., Muenster, Stefan, Brouckaert, Peter, Miller, Keith, Solt, Ken, Buys, Emmanuel S., Ichinose, Fumito, Zapol, Warren M.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2017
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471676/
https://ncbi.nlm.nih.gov/pubmed/28615047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12871-017-0368-5
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