Sensitivity to Sevoflurane anesthesia is decreased in mice with a congenital deletion of Guanylyl Cyclase-1 alpha

BACKGROUND: Volatile anesthetics increase levels of the neurotransmitter nitric oxide (NO) and the secondary messenger molecule cyclic guanosine monophosphate (cGMP) in the brain. NO activates the enzyme guanylyl cyclase (GC) to produce cGMP. We hypothesized that the NO-GC-cGMP pathway contributes t...

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Udgivet i:BMC Anesthesiol
Main Authors: Nagasaka, Yasuko, Wepler, Martin, Thoonen, Robrecht, Sips, Patrick Y., Allen, Kaitlin, Graw, Jan A., Yao, Vincent, Burns, Sara M., Muenster, Stefan, Brouckaert, Peter, Miller, Keith, Solt, Ken, Buys, Emmanuel S., Ichinose, Fumito, Zapol, Warren M.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471676/
https://ncbi.nlm.nih.gov/pubmed/28615047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12871-017-0368-5
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