The Ability of Nitric Oxide to Lower Intraocular Pressure Is Dependent on Guanylyl Cyclase

PURPOSE: While nitric oxide (NO) donors are emerging as treatments for glaucoma, the mechanism by which NO lowers intraocular pressure (IOP) is unclear. NO activates the enzyme guanylyl cyclase (GC) to produce cyclic guanosine monophosphate. We studied the ocular effects of inhaled and topically app...

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Veröffentlicht in:Invest Ophthalmol Vis Sci
Hauptverfasser: Muenster, Stefan, Lieb, Wolfgang S., Fabry, Gregor, Allen, Kaitlin N., Kamat, Shivani S., Guy, Ann H., Dordea, Ana C., Teixeira, Leandro, Tainsh, Robert E., Yu, Binglan, Zhu, Wei, Ashpole, Nicole E., Malhotra, Rajeev, Brouckaert, Peter, Bloch, Donald B., Scherrer-Crosbie, Marielle, Stamer, W. Daniel, Kuehn, Markus H., Pasquale, Louis R., Buys, Emmanuel S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Association for Research in Vision and Ophthalmology 2017
Schlagworte:
Glaucoma
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5624778/
https://ncbi.nlm.nih.gov/pubmed/28973329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-22168
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