The Ability of Nitric Oxide to Lower Intraocular Pressure Is Dependent on Guanylyl Cyclase

PURPOSE: While nitric oxide (NO) donors are emerging as treatments for glaucoma, the mechanism by which NO lowers intraocular pressure (IOP) is unclear. NO activates the enzyme guanylyl cyclase (GC) to produce cyclic guanosine monophosphate. We studied the ocular effects of inhaled and topically app...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Muenster, Stefan, Lieb, Wolfgang S., Fabry, Gregor, Allen, Kaitlin N., Kamat, Shivani S., Guy, Ann H., Dordea, Ana C., Teixeira, Leandro, Tainsh, Robert E., Yu, Binglan, Zhu, Wei, Ashpole, Nicole E., Malhotra, Rajeev, Brouckaert, Peter, Bloch, Donald B., Scherrer-Crosbie, Marielle, Stamer, W. Daniel, Kuehn, Markus H., Pasquale, Louis R., Buys, Emmanuel S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2017
Assuntos:
Glaucoma
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5624778/
https://ncbi.nlm.nih.gov/pubmed/28973329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-22168
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