Androgen-sensitive hypertension associated with soluble guanylate cyclase-α(1) deficiency is mediated by 20-HETE

Dysregulated nitric oxide (NO) signaling contributes to the pathogenesis of hypertension, a prevalent and often sex-specific risk factor for cardiovascular disease. We previously reported that mice deficient in the α(1)-subunit of the NO receptor soluble guanylate cyclase (sGCα(1)(−/−) mice) display...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Dordea, Ana C., Vandenwijngaert, Sara, Garcia, Victor, Tainsh, Robert E. T., Nathan, Daniel I., Allen, Kaitlin, Raher, Michael J., Tainsh, Laurel T., Zhang, Fan, Lieb, Wolfgang S., Mikelman, Sarah, Kirby, Andrew, Stevens, Christine, Thoonen, Robrecht, Hindle, Allyson G., Sips, Patrick Y., Falck, John R., Daly, Mark J., Brouckaert, Peter, Bloch, Kenneth D., Bloch, Donald B., Malhotra, Rajeev, Schwartzman, Michal L., Buys, Emmanuel S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2016
Assuntos:
Integrative Cardiovascular Physiology and Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935526/
https://ncbi.nlm.nih.gov/pubmed/27199131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00877.2015
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