Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice

Oxidative stress, a central mediator of cardiovascular disease, results in loss of the prosthetic haem group of soluble guanylate cyclase (sGC), preventing its activation by nitric oxide (NO). Here we introduce Apo-sGC mice expressing haem-free sGC. Apo-sGC mice are viable and develop hypertension....

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Publicado en:Nat Commun
Main Authors: Thoonen, Robrecht, Cauwels, Anje, Decaluwe, Kelly, Geschka, Sandra, Tainsh, Robert E., Delanghe, Joris, Hochepied, Tino, De Cauwer, Lode, Rogge, Elke, Voet, Sofie, Sips, Patrick, Karas, Richard H., Bloch, Kenneth D., Vuylsteke, Marnik, Stasch, Johannes-Peter, Van de Voorde, Johan, Buys, Emmanuel S., Brouckaert, Peter
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4699393/
https://ncbi.nlm.nih.gov/pubmed/26442659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9482
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