Nitrite protects against morbidity and mortality associated with TNF- or LPS-induced shock in a soluble guanylate cyclase–dependent manner

Nitrite (NO(2)(−)), previously viewed as a physiologically inert metabolite and biomarker of the endogenous vasodilator NO, was recently identified as an important biological NO reservoir in vasculature and tissues, where it contributes to hypoxic signaling, vasodilation, and cytoprotection after is...

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Hlavní autoři: Cauwels, Anje, Buys, Emmanuel S., Thoonen, Robrecht, Geary, Lisa, Delanghe, Joris, Shiva, Sruti, Brouckaert, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2009
Témata:
Brief Definitive Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806477/
https://ncbi.nlm.nih.gov/pubmed/19934018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091236
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