The Ability of Nitric Oxide to Lower Intraocular Pressure Is Dependent on Guanylyl Cyclase

PURPOSE: While nitric oxide (NO) donors are emerging as treatments for glaucoma, the mechanism by which NO lowers intraocular pressure (IOP) is unclear. NO activates the enzyme guanylyl cyclase (GC) to produce cyclic guanosine monophosphate. We studied the ocular effects of inhaled and topically app...

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Pubblicato in:Invest Ophthalmol Vis Sci
Autori principali: Muenster, Stefan, Lieb, Wolfgang S., Fabry, Gregor, Allen, Kaitlin N., Kamat, Shivani S., Guy, Ann H., Dordea, Ana C., Teixeira, Leandro, Tainsh, Robert E., Yu, Binglan, Zhu, Wei, Ashpole, Nicole E., Malhotra, Rajeev, Brouckaert, Peter, Bloch, Donald B., Scherrer-Crosbie, Marielle, Stamer, W. Daniel, Kuehn, Markus H., Pasquale, Louis R., Buys, Emmanuel S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Association for Research in Vision and Ophthalmology 2017
Soggetti:
Glaucoma
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5624778/
https://ncbi.nlm.nih.gov/pubmed/28973329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.17-22168
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