Sensitivity to Sevoflurane anesthesia is decreased in mice with a congenital deletion of Guanylyl Cyclase-1 alpha

BACKGROUND: Volatile anesthetics increase levels of the neurotransmitter nitric oxide (NO) and the secondary messenger molecule cyclic guanosine monophosphate (cGMP) in the brain. NO activates the enzyme guanylyl cyclase (GC) to produce cGMP. We hypothesized that the NO-GC-cGMP pathway contributes t...

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Dades bibliogràfiques
Publicat a:BMC Anesthesiol
Autors principals: Nagasaka, Yasuko, Wepler, Martin, Thoonen, Robrecht, Sips, Patrick Y., Allen, Kaitlin, Graw, Jan A., Yao, Vincent, Burns, Sara M., Muenster, Stefan, Brouckaert, Peter, Miller, Keith, Solt, Ken, Buys, Emmanuel S., Ichinose, Fumito, Zapol, Warren M.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471676/
https://ncbi.nlm.nih.gov/pubmed/28615047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12871-017-0368-5
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