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Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme

Crystal structures of enzymes are indispensable to understanding their mechanisms on a molecular level. It, however, remains challenging to determine which structures are adopted in solution, especially for dynamic complexes. Here, we study the bilobed decapping enzyme Dcp2 that removes the 5′ cap s...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Wurm, Jan Philip, Holdermann, Iris, Overbeck, Jan H., Mayer, Philipp H. O., Sprangers, Remco
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468633/
https://ncbi.nlm.nih.gov/pubmed/28533364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704496114
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