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Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme

Crystal structures of enzymes are indispensable to understanding their mechanisms on a molecular level. It, however, remains challenging to determine which structures are adopted in solution, especially for dynamic complexes. Here, we study the bilobed decapping enzyme Dcp2 that removes the 5′ cap s...

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Podrobná bibliografie
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Wurm, Jan Philip, Holdermann, Iris, Overbeck, Jan H., Mayer, Philipp H. O., Sprangers, Remco
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468633/
https://ncbi.nlm.nih.gov/pubmed/28533364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704496114
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