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The S. pombe mRNA decapping complex recruits cofactors and an Edc1-like activator through a single dynamic surface

The removal of the 5′ 7-methylguanosine mRNA cap structure (decapping) is a central step in the 5′–3′ mRNA degradation pathway and is performed by the Dcp1:Dcp2 decapping complex. The activity of this complex is tightly regulated to prevent premature degradation of the transcript. Here, we establish...

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Vydáno v:RNA
Hlavní autoři: Wurm, Jan Philip, Overbeck, Jan, Sprangers, Remco
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4986892/
https://ncbi.nlm.nih.gov/pubmed/27354705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.057315.116
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