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The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex

The Dcp1:Dcp2 decapping complex catalyses the removal of the mRNA 5′ cap structure. Activator proteins, including Edc3 (enhancer of decapping 3), modulate its activity. Here, we solved the structure of the yeast Edc3 LSm domain in complex with a short helical leucine-rich motif (HLM) from Dcp2. The...

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書誌詳細
主要な著者: Fromm, Simon A, Truffault, Vincent, Kamenz, Julia, Braun, Joerg E, Hoffmann, Niklas A, Izaurralde, Elisa, Sprangers, Remco
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261563/
https://ncbi.nlm.nih.gov/pubmed/22085934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.408
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