The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex

The Dcp1:Dcp2 decapping complex catalyses the removal of the mRNA 5′ cap structure. Activator proteins, including Edc3 (enhancer of decapping 3), modulate its activity. Here, we solved the structure of the yeast Edc3 LSm domain in complex with a short helical leucine-rich motif (HLM) from Dcp2. The...

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Hauptverfasser: Fromm, Simon A, Truffault, Vincent, Kamenz, Julia, Braun, Joerg E, Hoffmann, Niklas A, Izaurralde, Elisa, Sprangers, Remco
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261563/
https://ncbi.nlm.nih.gov/pubmed/22085934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.408
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