DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa

DCP1 stimulates the decapping enzyme DCP2, which removes the mRNA 5′ cap structure committing mRNAs to degradation. In multicellular eukaryotes, DCP1-DCP2 interaction is stabilized by additional proteins, including EDC4. However, most information on DCP2 activation stems from studies in S. cerevisia...

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Main Authors: Tritschler, Felix, Braun, Joerg E., Motz, Carina, Igreja, Catia, Haas, Gabrielle, Truffault, Vincent, Izaurralde, Elisa, Weichenrieder, Oliver
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789166/
https://ncbi.nlm.nih.gov/pubmed/19966221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909871106
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