DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa

DCP1 stimulates the decapping enzyme DCP2, which removes the mRNA 5′ cap structure committing mRNAs to degradation. In multicellular eukaryotes, DCP1-DCP2 interaction is stabilized by additional proteins, including EDC4. However, most information on DCP2 activation stems from studies in S. cerevisia...

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Detaylı Bibliyografya
Asıl Yazarlar: Tritschler, Felix, Braun, Joerg E., Motz, Carina, Igreja, Catia, Haas, Gabrielle, Truffault, Vincent, Izaurralde, Elisa, Weichenrieder, Oliver
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2009
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789166/
https://ncbi.nlm.nih.gov/pubmed/19966221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909871106
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