تحميل...
Active site conformational dynamics are coupled to catalysis in the mRNA decapping enzyme Dcp2
Removal of the 5′ cap structure by Dcp2 is a major step in several 5′–3′ mRNA decay pathways. The activity of Dcp2 is enhanced by Dcp1 and bound coactivators, yet the details of how these interactions are linked to chemistry are poorly understood. Here we report three crystal structures of the catal...
محفوظ في:
| المؤلفون الرئيسيون: | , , , , |
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| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
2013
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3769517/ https://ncbi.nlm.nih.gov/pubmed/23911090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.06.021 |
| الوسوم: |
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