Changes in conformational equilibria regulate the activity of the Dcp2 decapping enzyme

Crystal structures of enzymes are indispensable to understanding their mechanisms on a molecular level. It, however, remains challenging to determine which structures are adopted in solution, especially for dynamic complexes. Here, we study the bilobed decapping enzyme Dcp2 that removes the 5′ cap s...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Wurm, Jan Philip, Holdermann, Iris, Overbeck, Jan H., Mayer, Philipp H. O., Sprangers, Remco
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2017
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468633/
https://ncbi.nlm.nih.gov/pubmed/28533364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704496114
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