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The hDcp2 protein is a mammalian mRNA decapping enzyme

Decapping of mRNA is a critical step in eukaryotic mRNA turnover, yet the proteins involved in this activity remain elusive in mammals. We identified the human Dcp2 protein (hDcp2) as an enzyme containing intrinsic decapping activity. hDcp2 specifically hydrolyzed methylated capped RNA to release m(...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Wang, Zuoren, Jiao, Xinfu, Carr-Schmid, Anne, Kiledjian, Megerditch
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC130517/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12218187/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.192445599
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