Creatine mitigates neurogenesis impairment caused by defective DcpS decapping

Abstract Biallelic mutations in the DCPS gene disrupting the decapping activity of the scavenger decapping protein DcpS, leads to neurodevelopmental deficiencies and intellectual disability. However, the molecular basis for the neurogenesis defects in these individuals remains unknown. Here we show...

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Hlavní autoři:	Jun Yang, Geeta Palsule, Xinfu Jiao, Jaime S. Messenger, Ronald P. Hart, Megerditch Kiledjian
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2025-05-01
Edice:	Scientific Reports
Témata:	DcpS Decapping Neurogenesis Neuritogenesis Creatine supplementation
On-line přístup:	https://doi.org/10.1038/s41598-025-02961-5
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