3-Hydroxypyrimidine-2,4-Diones as Novel Hepatitis B Virus Antivirals Targeting the Viral Ribonuclease H

Hepatitis B virus (HBV) RNase H (RNH) is an appealing therapeutic target due to its essential role in viral replication. RNH inhibitors (RNHIs) could help to more effectively control HBV infections. Here, we report 3-hydroxypyrimidine-2,4-diones as novel HBV RNHIs with antiviral activity. We synthes...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Huber, Andrew D., Michailidis, Eleftherios, Tang, Jing, Puray-Chavez, Maritza N., Boftsi, Maria, Wolf, Jennifer J., Boschert, Kelsey N., Sheridan, Megan A., Leslie, Maxwell D., Kirby, Karen A., Singh, Kamalendra, Mitsuya, Hiroaki, Parniak, Michael A., Wang, Zhengqiang, Sarafianos, Stefan G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444124/
https://ncbi.nlm.nih.gov/pubmed/28320718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00245-17
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