3-Hydroxypyrimidine-2,4-Diones as Novel Hepatitis B Virus Antivirals Targeting the Viral Ribonuclease H

Hepatitis B virus (HBV) RNase H (RNH) is an appealing therapeutic target due to its essential role in viral replication. RNH inhibitors (RNHIs) could help to more effectively control HBV infections. Here, we report 3-hydroxypyrimidine-2,4-diones as novel HBV RNHIs with antiviral activity. We synthes...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Huber, Andrew D., Michailidis, Eleftherios, Tang, Jing, Puray-Chavez, Maritza N., Boftsi, Maria, Wolf, Jennifer J., Boschert, Kelsey N., Sheridan, Megan A., Leslie, Maxwell D., Kirby, Karen A., Singh, Kamalendra, Mitsuya, Hiroaki, Parniak, Michael A., Wang, Zhengqiang, Sarafianos, Stefan G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2017
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444124/
https://ncbi.nlm.nih.gov/pubmed/28320718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00245-17
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi