3-Hydroxypyrimidine-2,4-Diones as Novel Hepatitis B Virus Antivirals Targeting the Viral Ribonuclease H

Hepatitis B virus (HBV) RNase H (RNH) is an appealing therapeutic target due to its essential role in viral replication. RNH inhibitors (RNHIs) could help to more effectively control HBV infections. Here, we report 3-hydroxypyrimidine-2,4-diones as novel HBV RNHIs with antiviral activity. We synthes...

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Detaylı Bibliyografya
Yayımlandı:Antimicrob Agents Chemother
Asıl Yazarlar: Huber, Andrew D., Michailidis, Eleftherios, Tang, Jing, Puray-Chavez, Maritza N., Boftsi, Maria, Wolf, Jennifer J., Boschert, Kelsey N., Sheridan, Megan A., Leslie, Maxwell D., Kirby, Karen A., Singh, Kamalendra, Mitsuya, Hiroaki, Parniak, Michael A., Wang, Zhengqiang, Sarafianos, Stefan G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2017
Konular:
Antiviral Agents
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444124/
https://ncbi.nlm.nih.gov/pubmed/28320718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00245-17
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