3-Hydroxypyrimidine-2,4-Diones as Novel Hepatitis B Virus Antivirals Targeting the Viral Ribonuclease H

Hepatitis B virus (HBV) RNase H (RNH) is an appealing therapeutic target due to its essential role in viral replication. RNH inhibitors (RNHIs) could help to more effectively control HBV infections. Here, we report 3-hydroxypyrimidine-2,4-diones as novel HBV RNHIs with antiviral activity. We synthes...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Huber, Andrew D., Michailidis, Eleftherios, Tang, Jing, Puray-Chavez, Maritza N., Boftsi, Maria, Wolf, Jennifer J., Boschert, Kelsey N., Sheridan, Megan A., Leslie, Maxwell D., Kirby, Karen A., Singh, Kamalendra, Mitsuya, Hiroaki, Parniak, Michael A., Wang, Zhengqiang, Sarafianos, Stefan G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444124/
https://ncbi.nlm.nih.gov/pubmed/28320718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00245-17
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