3-Hydroxypyrimidine-2,4-Diones as Novel Hepatitis B Virus Antivirals Targeting the Viral Ribonuclease H

Hepatitis B virus (HBV) RNase H (RNH) is an appealing therapeutic target due to its essential role in viral replication. RNH inhibitors (RNHIs) could help to more effectively control HBV infections. Here, we report 3-hydroxypyrimidine-2,4-diones as novel HBV RNHIs with antiviral activity. We synthes...

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Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: Huber, Andrew D., Michailidis, Eleftherios, Tang, Jing, Puray-Chavez, Maritza N., Boftsi, Maria, Wolf, Jennifer J., Boschert, Kelsey N., Sheridan, Megan A., Leslie, Maxwell D., Kirby, Karen A., Singh, Kamalendra, Mitsuya, Hiroaki, Parniak, Michael A., Wang, Zhengqiang, Sarafianos, Stefan G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2017
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444124/
https://ncbi.nlm.nih.gov/pubmed/28320718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00245-17
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