Efficacy of the Investigational Antifungal VT-1161 in Treating Naturally Occurring Coccidioidomycosis in Dogs

Coccidioidomycosis can be a chronic, systemic fungal infection requiring long-term to lifetime medication. Thus, there is a need for improved antifungal agents with greater efficacy and reduced toxicity. VT-1161 has a low affinity for mammalian cytochromes and potently inhibits fungal CYP51 with pro...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Shubitz, Lisa F., Roy, Michael E., Trinh, Hien T., Hoekstra, William J., Schotzinger, Robert J., Garvey, Edward P.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5404554/
https://ncbi.nlm.nih.gov/pubmed/28289027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00111-17
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