The Novel Fungal Cyp51 Inhibitor VT-1598 Is Efficacious in Experimental Models of Central Nervous System Coccidioidomycosis Caused by Coccidioides posadasii and Coccidioides immitis

Coccidioidal meningitis can cause significant morbidity, and lifelong antifungal therapy is often required. VT-1598 is a fungus-specific Cyp51 inhibitor that has potent in vitro activity against Coccidioides species. We evaluated the in vivo efficacy of VT-1598 in murine models of central nervous sy...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Wiederhold, Nathan P., Shubitz, Lisa F., Najvar, Laura K., Jaramillo, Rosie, Olivo, Marcos, Catano, Gabriel, Trinh, Hien T., Yates, Christopher M., Schotzinger, Robert J., Garvey, Edward P., Patterson, Thomas F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913997/
https://ncbi.nlm.nih.gov/pubmed/29437615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02258-17
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados