The Novel Fungal Cyp51 Inhibitor VT-1598 Is Efficacious in Experimental Models of Central Nervous System Coccidioidomycosis Caused by Coccidioides posadasii and Coccidioides immitis

Coccidioidal meningitis can cause significant morbidity, and lifelong antifungal therapy is often required. VT-1598 is a fungus-specific Cyp51 inhibitor that has potent in vitro activity against Coccidioides species. We evaluated the in vivo efficacy of VT-1598 in murine models of central nervous sy...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Wiederhold, Nathan P., Shubitz, Lisa F., Najvar, Laura K., Jaramillo, Rosie, Olivo, Marcos, Catano, Gabriel, Trinh, Hien T., Yates, Christopher M., Schotzinger, Robert J., Garvey, Edward P., Patterson, Thomas F.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5913997/
https://ncbi.nlm.nih.gov/pubmed/29437615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02258-17
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