CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

Unfolded and malfolded client proteins impose a stress on the endoplasmic reticulum (ER), which contributes to cell death in pathophysiological conditions. The transcription factor C/EBP homologous protein (CHOP) is activated by ER stress, and CHOP deletion protects against its lethal consequences....

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Autori principali: Marciniak, Stefan J., Yun, Chi Y., Oyadomari, Seiichi, Novoa, Isabel, Zhang, Yuhong, Jungreis, Rivka, Nagata, Kazuhiro, Harding, Heather P., Ron, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2004
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC535917/
https://ncbi.nlm.nih.gov/pubmed/15601821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1250704
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