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Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes
Overload of pancreatic β cells in conditions such as hyperglycemia, obesity, and long-term treatment with sulfonylureas leads to β cell exhaustion and type 2 diabetes. Because β cell mass declines under these conditions, apparently as a result of apoptosis, we speculated that overload kills β cells...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2002
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC150879/ https://ncbi.nlm.nih.gov/pubmed/11854325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI14550 |
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