CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

Unfolded and malfolded client proteins impose a stress on the endoplasmic reticulum (ER), which contributes to cell death in pathophysiological conditions. The transcription factor C/EBP homologous protein (CHOP) is activated by ER stress, and CHOP deletion protects against its lethal consequences....

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Detalles Bibliográficos
Publicado en:Genes Dev
Main Authors: Marciniak, Stefan J., Yun, Chi Y., Oyadomari, Seiichi, Novoa, Isabel, Zhang, Yuhong, Jungreis, Rivka, Nagata, Kazuhiro, Harding, Heather P., Ron, David
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2004
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC535917/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15601821/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1250704
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