Loading...
Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers
Circulating polymers of α1-antitrypsin (α1AT) are neutrophil chemo-attractants and contribute to inflammation, yet cellular factors affecting their secretion remain obscure. We report on a genome-wide CRISPR-Cas9 screen for genes affecting trafficking of polymerogenic α1AT(H334D). A CRISPR enrichmen...
Saved in:
| Published in: | Cell Rep |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Cell Press
2021
|
| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8149808/ https://ncbi.nlm.nih.gov/pubmed/34010647 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109144 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|