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Cargo receptor-assisted endoplasmic reticulum export of pathogenic α1-antitrypsin polymers
Circulating polymers of α1-antitrypsin (α1AT) are neutrophil chemo-attractants and contribute to inflammation, yet cellular factors affecting their secretion remain obscure. We report on a genome-wide CRISPR-Cas9 screen for genes affecting trafficking of polymerogenic α1AT(H334D). A CRISPR enrichmen...
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| Publicado no: | Cell Rep |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cell Press
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8149808/ https://ncbi.nlm.nih.gov/pubmed/34010647 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109144 |
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