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Protein-Folding Homeostasis in the Endoplasmic Reticulum and Nutritional Regulation
The flux of newly synthesized proteins entering the endoplasmic reticulum (ER) is under negative regulation by the ER-localized PKR-like ER kinase (PERK). PERK is activated by unfolded protein stress in the ER lumen and inhibits new protein synthesis by the phosphorylation of translation initiation...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3504434/ https://ncbi.nlm.nih.gov/pubmed/23209157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a013177 |
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