Intact protein folding in the glutathione-depleted endoplasmic reticulum implicates alternative protein thiol reductants

Protein folding homeostasis in the endoplasmic reticulum (ER) requires efficient protein thiol oxidation, but also relies on a parallel reductive process to edit disulfides during the maturation or degradation of secreted proteins. To critically examine the widely held assumption that reduced ER glu...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Tsunoda, Satoshi, Avezov, Edward, Zyryanova, Alisa, Konno, Tasuku, Mendes-Silva, Leonardo, Pinho Melo, Eduardo, Harding, Heather P, Ron, David
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2014
Sujets:
Cell Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109312/
https://ncbi.nlm.nih.gov/pubmed/25073928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03421
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