Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models

A novel pathway of vitamin D(3) (D(3)) metabolism, initiated by C20-hydroxylation of D(3) by CYP11A1, has been confirmed to operate in vivo. Its major product, 20(OH)D(3), exhibits antiproliferative activity in vitro comparable to that of 1,25(OH)(2)D(3), but is noncalcemic in mice and rats. To furt...

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Detalles Bibliográficos
Publicado en:Oncotarget
Autores principales: Skobowiat, Cezary, Oak, Allen S.W., Kim, Tae-Kang, Yang, Chuan He, Pfeffer, Lawrence M., Tuckey, Robert C., Slominski, Andrzej T.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354773/
https://ncbi.nlm.nih.gov/pubmed/28039464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14193
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