20S-Hydroxyvitamin D(3), Noncalcemic Product of CYP11A1 Action on Vitamin D(3), Exhibits Potent Antifibrogenic Activity in Vivo

CONTEXT: There is no effective treatment for systemic sclerosis and related fibrosing diseases. Recently the action of CYP11A1 on vitamin D(3) was shown to produce biologically active 20S-hydroxyvitamin D [20(OH)D(3)] and 20,23(OH)(2)D(3), 20,22(OH)(2)D(3), and 17,20,23(OH)(3)D(3). OBJECTIVES: Becau...

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Detalhes bibliográficos
Main Authors: Slominski, Andrzej, Janjetovic, Zorica, Tuckey, Robert C., Nguyen, Minh N., Bhattacharya, Keka G., Wang, Jin, Li, Wei, Jiao, Yan, Gu, Weikuan, Brown, Monica, Postlethwaite, Arnold E.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
Assuntos:
JCEM Online: Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565109/
https://ncbi.nlm.nih.gov/pubmed/23295467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2012-3074
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