20-Hydroxyvitamin D(2) is a noncalcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells

20-hydroxyvitamin D(2) [20(OH)D(2)] inhibits DNA synthesis in epidermal keratinocytes, melanocytes, and melanoma cells in a dose- and time-dependent manner. This inhibition is dependent on cell type, with keratinocytes and melanoma cells being more sensitive than normal melanocytes. The antiprolifer...

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Hlavní autoři: Slominski, Andrzej T., Kim, Tae-Kang, Janjetovic, Zorica, Tuckey, Robert C., Bieniek, Radoslaw, Yue, Junming, Li, Wei, Chen, Jianjun, Nguyen, Minh N., Tang, Edith K. Y., Miller, Duane, Chen, Tai C., Holick, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2011
Témata:
Growth, Differentiation, And Apoptosis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063966/
https://ncbi.nlm.nih.gov/pubmed/21160030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00203.2010
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