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Design, Synthesis and Biological Action of 20R-Hydroxyvitamin D3
Non-naturally occurring 20R epimer of 20-hydroxyvitamin D3 is synthesized based on chemical design and hypothesis. The 20R isomer is separated from semi-preparative HPLC and its structure is characterized. The comparison of 20R isomer to its 20S counterpart in biological evaluation demonstrates they...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3332540/ https://ncbi.nlm.nih.gov/pubmed/22404326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201478e |
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