Design, Synthesis and Biological Activities of Novel Gemini 20S-Hydroxyvitamin D(3) Analogs

Vitamin D(3) (D(3)) can be metabolized by cytochrome P450scc (CYP11A1) into 20S-hydroxyvitamin D(3) (20D(3)) as a major metabolite. This bioactive metabolite has shown strong antiproliferative, antifibrotic, pro-differentiation and anti-inflammatory effects while being non-toxic (non-calcemic) at hi...

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Detalhes bibliográficos
Publicado no:Anticancer Res
Main Authors: LIN, ZONGTAO, MAREPALLY, SRINIVASA R., KIM, TAE-KANG, JANJETOVIC, ZORICA, OAK, ALLEN SW., POSTLETHWAITE, ARNOLD E., MYERS, LINDA K., TUCKEY, ROBERT C., SLOMINSKI, ANDRZEJ T., MILLER, DUANE D., LI, WEI
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363177/
https://ncbi.nlm.nih.gov/pubmed/26976974
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